Science Proves Resveratrol Treats Gout

Science Proves It –

Resveratrol Treats Gout

 

 

Gout is a form of inflammatory arthritis. It is caused due to the buildup of uric acid crystals in the joints or elevated levels of uric acid in the blood. It is characterized by sudden attacks of pain, red, hot and swollen joints. It leads to a big toe which is pain and inflammation in the joint at the base of the big toe.

Gout may lead to other conditions like kidney stones, tophi or urate nephropathy. It occurs due to a combination of diet and genetic factors. There are various nonsteroidal drugs and steroids that are involved in the treatment of gout. However, changes in lifestyle and diet can play a major role in preventing gout.

However, changes in lifestyle and diet can play a major role in preventing gout.Occurrence of gout has been strongly associated with dietary patterns like consumption of alcohol,

The occurrence of gout has been strongly associated with dietary patterns like consumption of alcohol, fructose-sweetened drinks, meat, and seafood. It occurs due to consuming foods high in purines. Foods containing high purines are liver, beans, and meat (beef, pork) and beer.

On the other hand, there are various foods that can be incorporated in the diet to reduce the risk of gout. Resveratrol, a component of foods like the skin of grapes and raspberries has been found to have a preventative effect on the treatment of gout in arthritis.

 

 

 

What is Resveratrol?

 

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Resveratrol is a natural phenol that possesses mainly antioxidant and antimicrobial properties. It is produced by numerous plants under conditions of stress like in response to an injury or when attacked by a pathogen such as bacteria or fungi.

Resveratrol is found in foods like the skin of grapes, blueberries, raspberries, mulberries, and ligonberry. The consumption of resveratrol has found to be beneficial for curing symptoms like inflammation, sudden attacks and swelling in patients who are suffering from gout arthritis.

 

 

Proven Benefits of Reseveratrol as a Gout Treatment

 

Resveratrol Reduces Inflammation in Gout

 

Resveratrol is found to inhibit inflammation in the joints of patients suffering from Gout. It reduces levels of uric acids, prevents sudden attacks, inhibits inflammation and other related symptoms of Gout.

Experimental studies have revealed the therapeutic and preventative effect of resveratrol in preventing symptoms related to gout. One such recent study published in the Journal of clinical rheumatology in 2016 was performed on the animal model.

The results indicated resveratrol inhibited inflammation and swelling in the joints. It also reduced the serum uric acid levels.

The study concluded that resveratrol has the ability to prevent sudden attacks, inhibit inflammation and reduce serum uric acid levels in gout arthritis.

Another experimental study revealed the anti-inflammatory activity of resveratrol on addition with sodium alginate which is a pharmaceutic adjuvant on acute gout arthritis. It was observed that resveratrol had a better effect over colchichine, a medication commonly used to treat gout.

 

 

Resveratrol is a Natural Antioxidant

 

Resveratrol has anti-oxidant effects which can prevent pain and swelling in the joints associated with gout.

Resveratrol shows anti-oxidative properties which can prove to be essential in curing gout arthritis. An experimental study suggested that resveratrol when used alone or in combination with sodium alginate which is a pharmaceutic adjuvant, has beneficial effects in curing acute gout.

Its anti-oxidative effect can help in reducing the oxidation of uric acid accumulated in the joints hence relieving pain and swelling. Research identifies the benefit of antioxidant property of resveratrol in diseases like cancer.

Research shows that by counteracting harmful reactive oxygen species (agents that cause an oxidative imbalance in the body if not controlled) resveratrol alleviates pain and inflammation in arthritis.

 

Resveratrol Prevents Uric Acid Buildup in Gout

 

Resveratrol reduces levels of uric acid in the blood which is found in significant amounts in patients suffering from gout. High uric acid levels is the first indicator of Gout and Resveratrol can be used to reduced it’s levels hence preventing occurrence of the disease.

In an animal study performed by Shi et al. in 2012, resveratrol was found to possess anti-hyperuricemic activities i.e. it was capable of reducing the uric acid levels. Thus, indicating its ability in curing gout.

In a study conducted by Silan et al. Blood urea levels were found to increase in animal model treated with gentamicin antibiotic. The study showed that treatment with resveratrol showed a significant decrease in lipid peroxidation and reduced activity of catalase.

Levels of urea and creatine were found to decrease in treatment with resveratrol than with gentamicin.

 

 

Resveratrol Protects Kidney Health in Gout

 

Gout leads to nephropathy. Resveratrol shows protective effect against nephrotoxicity and can be beneficial in treating nephropathy associated with Gout.

Acute uric acid nephropathy, chronic urate nephropathy, and uric acid nephrolithiasis are three forms of kidney diseases that are closely associated with gout.

An experimental study published in the Journal of Molecular nutrition and food research in 2012 described an experiment conducted to evaluate the nephroprotective effects of resveratrol. Resveratrol along with its analogs were found to prevent nephropathy in an animal model of gout.

In another study conducted by Silan et al.histopathological examination results showed that resveratrol had a protective effect against nephrotoxicity caused by gentamicin, lipid peroxidation, and cellular damage.

In an experimental study, the protective effect of Resveratrol was determined on nephrotoxicity in an animal model. Resveratrol alleviated nephrotoxicity by its antioxidant capacity. The study concluded that Resveratrol has the potential to protect against kidney damage in people exposed to carcinogen arsenic.

 

 

Resveratrol Reduces Blood Pressure and Protects Heart Health

 

Resveratrol shows protective effects in cardiovascular and renal diseases whose development is associated with Gout.

In an experimental study published by Braz et al.in 2015 suggested that High uric acid levels as seen in Gout increase risk of renal disorders like chronic kidney disease, hypertension, and acute kidney injury.

Studies have confirmed that increase in uric acid levels is related to hypertension. Resveratrol was found to inhibit oxidation of bad cholesterol, mitigation of liver disease, fat reduction, improvements in muscle function and cardiovascular and renal protection.

Resveratrol has effectively found to reduce hypertension including improvement in oxidative stress, inflammation, endothelial dysfunction, and vasodilation.

According to a study conducted by Kitada et al. Beneficial effects of Resveratrol on cardiovascular and renal diseases is due to its anti-oxidant properties against the reactive oxygen species.

 

 

Resveratrol Dosage for Gout

 

Plant-derived natural components like resveratrol are safe and effective when taken at a low dose. They may have toxic or side effects when taken in high doses. Similarly, resveratrol benefits are dose dependent.

Low doses of resveratrol have protective effects on the health whereas high doses can be detrimental to health. For curing pathological conditions like cancer, high doses may be required under a doctors supervision.

Research studies show results of many doses of resveratrol. Resveratrol has not shown any toxic effects in humans but there are only a few studies supporting this evidence so far. A study conducted on ten human participants revealed that oral dosage of 5000 mg of resveratrol did not result in any adverse side effects.

Oral doses of 5-25 mg of Resveratrol is recommended for daily consumption.

 

 

Resveratrol Precautions

 

So far no studies indicate any adverse side effects of consumption or application of resveratrol. It is considered to be safe when consumed in amounts present in the foods. However, no side effects have been seen when resveratrol is consumed in high doses.

During pregnancy, resveratrol can be consumed in the amounts present naturally in foods. Alcohol must be avoided by pregnant and breastfeeding women.

Resveratrol might slow blood clotting and increase the risk of bleeding. It must, therefore, be avoided by people suffering from bleeding disorders like Hemophilia. Due to the same reason, its intake must be avoided two weeks prior by people who are going to undergo a surgery.

People already on medication for other diseases must consult a doctor before consuming resveratrol as it can react with their drugs and lower their effectiveness.

 

 

Final Thoughts

 

Gout is a life altering disease. There is an urgent need to look into the treatment related to Gout as more and more number of people are suffering from this disease as the years are passing by.

Resveratrol supplements promise to be an effective alternative to drugs involved in the treatment of gout. It is naturally occurring and has no adverse effects on consumption or application.

It’s anti-inflammatory, anti-oxidant and other effective properties can prove to beneficial in alleviating symptoms related to gout. But it is essential that one brings changes in his lifestyle like dietary changes and moderate exercise along with Resveratrol supplements that can help prevention of gout-related symptoms.

 

 

 

 

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Studies Show Blackcurrant Seed Oil Helps Arthritis

Studies Show Blackcurrant Seed Oil Helps Arthritis

 

 

Blackcurrant is a shrub native to Europe and Asia. It has yellowish white flowers and black fruits. Blackcurrant seed oil as the name suggests is extracted from the seeds of these fruits. Jams, jellies, juices and even dietary supplements are prepared from blackcurrant.

The fruits are rich in Vitamin C, flavonoids, anthocyanins, proanthocyanidins etc. The oil contains around 15-19% fatty acids: gamma and alpha linolenic acid and stearidonic acid as well as anthocyanidins and flavonoids.

In Chinese folk medicine, blackcurrant has been used as a dieuretic, diaphoretic and anti-pyretic. Traditionally they have been used to treat cold and flu.

The leaves are used to treat diarrhea, spasmodic cough and sore throat. Blackcurrant seed oil has antioxidant, anti-inflammatory, cardioprotective, immunostimulant, skin protective properties.

Blackcurrant seed oil is found to beneficial for immune system, heart health, dry eyes, premenstrual syndrome and psoriasis.

Blackcurrant seed oil contains around 15-20g of gamma linoleic acid and 12-14g of alpha linoleic acid which have an anti-inflammatory effect. If taken in high doses, blackcurrant oil can worsen inflammation, but at small doses it works as anti-inflammatory agent.

 

 

Studies Prove Blackcurrant Seed Oil Helps Arthritis

 

 

Blackcurrant Seed Oil Reduces Inflammation

 

Polyunsaturated fats are considered healthy fat since they are beneficial for metabolic and heart health. Blackcurrant seed oil serves as a source of PUFAs which aid in treatment of inflammation.

Blackcurrant seed oil is rich in an essential fatty acid called Gamma Linolenic acid(GLA). GLA is produced in the body from linoleic acid which is further metabolized to dihomogamma linolenic acid.

This is further metabolized by inflammatory enzymes COX and LOX to anti-inflammatory chemicals called eicosanoids. GLA and its metabolites also affect various genes that control immune function and cell death. Thus GLA works as anti-inflammatory agent.

GLA supplementation is found to inhibit activation of immune cells and prevent release of inflammatory chemicals from the immune cells of rheumatoid arthritis patients.

Synovial fluid is the fluid present in joints that lubricate the joints and reduces friction. Dihomogamma linoleic acid, a metabolite of GLA is found to reduce synovial fluid inflammation in arthritis.

A 6 month clinical trial was conducted where patients with rheumatoid arthritis received 2.8g GLA per day. 14 out of 22 patients showed improvement in GLA treated group while at 12 months 16 out of 21 showed meaningful improvement.

Researchers concluded that GLA is a safe and effective treatment for rheumatoid arthritis, and a combination of omega 3 fatty acids and GLA is found to be beneficial in treatment of rheumatoid arthritis.

 

Shop for Blackcurrant Seed oil on Amazon.

 

 

 

Blackcurrant Seed Oil for Arthritis Pain Relief

 

Clinical trials investigating the effect of blackcurrant seed oil in arthritis demonstrate that it can reduce symptoms of arthritis as well as inflammation on long term. It also suppresses inflammation in gout.A review examining different herbal therapies for arthritis mentions that blackcurrant seed oil does relieve symptoms of rheumatoid arthritis.Leventhal et. al conducted a clinical trial of 24 weeks where patients with rheumatoid arthritis were treated with blackcurrant seed oil capsules. Reduction in signs and symptoms were seen in group receiving blackcurrant seed oil.

However many patients withdrew from the study because it involved consuming large number of capsules.

A study was conducted where individuals suffering from rheumatoid arthritis were given dietary supplements of blackcurrant seed oil. A significant improvement in morning stiffness was observed with blackcurrant seed oil consumption.

When immune cells of these volunteers were studied, it was observed that these immune cells produced reduced amounts of inflammatory chemicals. In other words it was observed that blackcurrant seed oil supplementation reduced inflammation in rheumatoid arthritis patients.

Animal studies show that GLA and blackcurrant seed oil suppress inflammation in gout.

 

 

Blackcurrant Oil Improves Metabolic Health

 

A 2 month clinical trial on elderly individuals demonstrated that blackcurrant seed oil improves immune function.

Animal studies show that blackcurrant oil consumption improves antioxidant status, reduces liver fat, improves blood lipids and reduces cholesterol levels.

Tahvonen et. al in their clinical trial reported that 3g of blackcurrant seed oil per day improves the blood lipid profile and reduces the level of bad cholesterol. Blackcurrant seed oil is also proven to be beneficial for blood pressure control.

 

What does this mean?
Blackcurrant seed oil supplementation brings about favorable change in metabolic health and also boosts immune function.

 

 

Dosage

 

Blackcurrant seed oil is available in bottles as well as capsules. Blackcurrant seed oil can also be used topically for inflamed joints and skin irritation.

In the clinical trial blackcurrant seed oil has been used to a dose of 525 mg of gamma linolenic acid and 10.5g oil in another study. A dose of 1g of blackcurrant oil daily is recommended and found to be safe.

If taking capsules follow the dosage as prescribed by manufacturer or consult a doctor.

 

Shop for Blackcurrant Seed oil on Amazon.

 

 

 

Precautions

 

If taken in high doses, blackcurrant seed oil could cause side effects like headache, diarrhea, constipation and gas. If pregnant or lactating, avoid using blackcurrant seed oil.

Blackcurrant seed oil should be avoided with anticoagulants such as warfarin, since gamma linolenic acid can increase bleeding risk. Epilepsy patients and those taking antipsychotic drugs should use blackcurrant seed oil with caution.

 

 

Conclusion

 

 

Blackcurrant seed oil is rich in essential fatty acid Gamma linolenic acid which is metabolized in the body to produce anti-inflammatory chemicals, thus helping to reduce arthritic pain and inflammation.

Studies show the therapeutic efficacy of blackcurrant seed oil particularly in rheumatoid arthritis and gout, so one can assume it may also be effective as a complementary therapy in treating any form of arthritis.

 

Recommended: Now Black Currant Oil – 500 mg (70 mg GLA/100 Softgels).   Now Black Currant Oil is rated 4.6 out of 5, and has over 140 customer reviews on Amazon.

 

 

 

 

 

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You Can Fight Gout

 

 

 

Gout is a kind of arthritis. It can cause an attack of sudden burning pain, stiffness, and swelling in a joint, usually a big toe. These attacks can happen over and over unless gout is treated. Over time, they can harm your joints, tendons, and other tissues. Gout is most common in men.

 

Gout is caused by too much uric acid in the blood (hyperuricemia). Most of the time, having too much uric acid isn’t harmful. Many people with high levels in their blood never get gout. But when uric acid levels in your blood are too high, the uric acid may form hard crystals in your joints. The exact cause of hyperuricemia sometimes isn’t known, although inherited factors (genes) seem to play a role. 

 

Your chances of getting gout are higher if you are overweight, drink too much alcohol, or eat too much meat and fish that are high in chemicals called purines. Some medicines, such as water pills (diuretics), can also bring on gout.

 

The most common sign of gout is a nighttime attack of swelling, tenderness, redness, and sharp pain in your big toe. You can also get gout attacks in your foot, ankle, or knees, or other joints. The attacks can last a few days or many weeks before the pain goes away. Another attack may not happen for months or years.

 

See your doctor even if your pain from gout is gone. The buildup of uric acid that led to your gout attack can still harm your joints.

 

Your doctor will ask questions about your symptoms and do a physical exam. Your doctor may also take a sample of fluid from your joint to look for uric acid crystals. This is the best way to test for gout. Your doctor may also do a blood test to measure the amount of uric acid in your blood.

 

To stop a gout attack, your doctor can give you a shot of corticosteroids or prescribe a large daily dose of one or more medicines. The doses will get smaller as your symptoms go away. Relief from a gout attack often begins within 24 hours if you start treatment right away.

 

Recommended: The Mangano Method:  An All-Natural Approach to Fight Gout

 

 

Symptoms of Gout:

 

  • Warmth, pain, swelling, and extreme tenderness in a joint, usually a big toe joint . This symptom is called podagra. The pain often starts during the night. It may get worse quickly, last for hours, and be so intense that even light pressure from a sheet is intolerable
  • Very red or purplish skin around the affected joint. The joint may appear to be infected
  • Limited movement in the affected joint
  • Peeling and itching of the skin around the affected joint as the gout gets better

 

 

Gout Risk Factors

 

Things You Can’t Change

 

  • Being male
  • Having a family history of gout
  • Having been born with a rare condition that causes high blood uric acid levels, such as Kelley-Seegmiller syndrome or Lesch-Nyhan syndrome

 

 

Medicines That May Increase Uric Acid

 

  • Regular use of aspirin (more than 1 or 2 aspirin a day) or niacin
  • Diuretic medicines
  • Chemotherapy medicines (usually used to treat cancer)
  • Medicines that suppress the immune system, such as cyclosporine, that are used to prevent your body from rejecting an organ transplant

 

 

Conditions Related to Diet and Body Weight

 

  • Obesity (this is the easiest fat loss diet I have found )
  • Moderate, regular, or heavy use of alcohol, especially beer
  • A diet rich in meat and seafood, which can be high in purines
  • Frequent episodes of dehydration
  • Very low-calorie diets

 

 

Other Conditions

 

Certain other conditions and diseases appear more often in people who have gout than in people who don’t, though studies have not shown a clear relationship. Gout may share risk factors (such as obesity, hypertension, and high levels of triglycerides) with certain diseases, including:

 

  • Lead poisoning
  • Hardening of the arteries (atherosclerosis)
  • Conditions that cause an abnormal rapid turnover of cells, such as psoriasis, multiple myeloma, hemolytic anemia, or tumors
  • Acute illness or infection
  • Injury to a joint
  • Rapid weight loss, as might happen in hospitalized patients who have changes in diet or medicines
  • Surgery

 

Call or see your doctor right away if you have:

 

  • Severe pain in a single joint that comes on very quickly
  • Swollen, tender joints with warm, red skin over them

 

It’s important to see your doctor even if the pain from gout has stopped. The uric acid buildup that caused your gout attack may still be irritating your joints and could eventually cause serious damage. Your doctor can prescribe medicines that can prevent and even reverse the uric acid buildup.

 

 

Exams and Tests for Gout

 

  • A joint fluid analysis (arthrocentesis) to see whether uric acid crystals are present. This is the only certain way to diagnose gout
  • A medical history and physical exam
  • A test to measure levels of uric acid in blood. This may be done if your doctor cannot safely get fluid from the affected joint
  • A test to measure levels of uric acid in urine

 

While X-rays of extremities (hands and feet) are sometimes useful in the late stages of the disease, X-rays aren’t usually helpful in the early diagnosis. Pain often causes people to seek medical attention before any long-term changes can be seen on an X-ray. But X-rays may help to rule out other causes of arthritis.

 

Your doctor may evaluate you for lead poisoning if you have been exposed to lead in your job or through hobbies.

 

Recommended: The Mangano Method:  An All-Natural Approach to Fight Gout

 

 

Treatment

 

The goals of treatment for gout are fast pain relief and prevention of future gout attacks and long-term complications, such as joint destruction and kidney damage. Treatment includes medicines and steps you can take at home to prevent future attacks.

 

Specific treatment depends on whether you are having an acute attack or are trying to manage long-term gout and prevent future attacks.

 

To Treat an Acute Attack

 

  • Rest the affected joint(s)
  • Use ice to reduce swelling
  • Take short-term medicines at the first sign of a gout attack, as prescribed by your doctor
    • Nonsteroidal anti-inflammatory drugs (NSAIDs)
    • Colchicine
    • Oral corticosteroids

 

 

Home Treatment

 

If you have been diagnosed with gout, you can do a lot on your own to treat your condition.

 

To Decrease the pain of an acute attack

 

Rest the affected joint until the attack eases and for 24 hours after the attack.

Elevate painful joints.

Use ice to reduce swelling.

Relieve inflammation by taking nonsteroidal anti-inflammatory drugs (NSAIDs). But don’t take aspirin, which may abruptly change uric acid levels and may make symptoms worse. Be safe with medicines. Read and follow all instructions on the label.

 

To Prevent more attacks

 

  • Control your weight. Being overweight increases your risk for gout. If you are overweight, a diet that is low in fat may help you lose weight. But avoid fasting or very low-calorie diets. Very low-calorie diets increase the amount of uric acid produced by the body and may bring on a gout attack.  See the fat loss diet I recommend.

 

  • Follow a moderate exercise program.

 

  • Limit alcohol, especially beer. Alcohol can reduce the release of uric acid by the kidneys into your urine, causing an increase of uric acid in your body. Beer, which is rich in purines, appears to be worse than some other beverages that contain alcohol.

 

  • Limit meat and seafood. Diets high in meat and seafood (high-purine foods) can raise uric acid levels.  In the past, gout was thought to be caused by drinking too much alcohol and eating too many rich foods. It is important to note that although eating certain foods and drinking alcohol may trigger a rise in the level of uric acid in the body, these habits may not by themselves cause gout. Gout is most often caused by an overproduction of uric acid (due to metabolism problems) or decreased elimination of uric acid by the kidneys.

 

  • Talk to your doctor about all the medicines you take.  Some medicines may raise the uric acid level.  Continue to take the medicines prescribed to you for gout. But if you weren’t taking medicines that lower uric acid (such as allopurinol or probenecid) before the attack, don’t start taking them when the attack begins. These medicines won’t help relieve acute pain. They may actually make it worse.

 

 

 

Medicine Choices

 

Medicine treatment for gout usually involves some combination of short- and long-term medicines.

 

 Short-term medicines

 

Short-term medicine relieves pain and reduces inflammation during an acute attack or prevents a recurrence of an acute attack.

These medicines may include:

 

  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, indomethacin, or naproxen. Do not take aspirin, which should never be used to relieve pain during a gout attack. Aspirin may change uric acid levels in the blood and may make the attack worse. Be safe with medicines. Read and follow all instructions on the label
  • Colchicine
  • Corticosteroids, which may be given in pills or as a shot for cases of gout that don’t respond to NSAIDs or colchicines

 

If treatment is started right away, relief from symptoms often occurs within 24 hours.

 

During a gout attack, your doctor will prescribe a maximum daily dose of one or more medicines used for short-term treatment to stop the attack. Doses are then reduced as the symptoms go away.

 

Long-term medicines

 

Long-term treatment uses medicines to lower uric acid levels in the blood. This can reduce how often you have gout attacks and how severe they are. These medicines may include:

 

  • Uricosuric agents, to increase elimination of uric acid by the kidneys
  • Xanthine oxidase inhibitors, to decrease production of uric acid by the body
  • Colchicine, to prevent flare-ups during the first months that you are taking medicines that lower uric acid
  • Pegloticase (Krystexxa). This medicine is for gout that has lasted a long time and hasn’t responded to other treatment

 

If your doctor prescribes medicine to lower your uric acid levels, be sure to take it as directed. Most people will continue to take this medicine every day. It is also important to know how to take it.

 

  • If you’re taking one of these medicines, continue to take the medicine during the attack
  • If you have one of these medicines but have not been taking it, do not start taking the medicine during an attack. Starting these medicines while you are having a gout attack can make your attack much worse

 

 

 

Complimentary Treatment

 

  • An herb called devil’s claw have been used as anti-inflammatories. Research shows it may be useful as a complementary medicine to treat gout.
  • Some studies show that folic acid may be helpful in inhibiting the enzyme needed to produce uric acid.

 

Sundown Naturals Folic Acid 400mcg 350 Tablets

 

 

Surgery

 

If gout symptoms have occurred off and on without treatment for more than 10 years, uric acid crystals may have built up in the joints to form gritty, chalky nodules called tophi. If tophi are causing infection, pain, pressure, and deformed joints, your doctor may be able to treat them with medicine. If this doesn’t work, your doctor may recommend surgery to remove them.

 

 

 

 

Best Recommendation: The Mangano Method:  An All-Natural Approach to Fight Gout

 

Fight Gout is a  powerful system to treat gout and relieve the symptoms using alternative methods with no prescription medications whatsoever.  Read more details about the program here.

 

 

 

 

 

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